I don't know what to do
Don't worry, I'll help
I'm at a loss as to what to do
I'm unable to decide for myself
What shall I do? /What should I do?
What am I supposed to do? 我该怎么办? *be supposed to计划做…
I don't know. Just relax, I'll help you
What am I going to do?
We can't finish our proposal in time
We are in trouble. 我们这下麻烦了
We're in big trouble
Do you like the new computer system?
No, it's a hassle. 不喜欢，那很麻烦
It's a pain in the neck
It's a pain in the ass. *低俗的说法。
It's a lot of trouble
What should we do?
I don't know
It's really a difficult problem. 这真是个难题
It's big problem
I don't know what to say. 我不知道说什么才好
I'm at a loss as to what to say. *困惑
I have a full house. 我是同花顺（打牌时）
You got me. 这下可难住我了
I don't know
I guess you're right
You win. /That beats me
He's a nuisance. *他特招人讨厌
You asked for it. 自作自受
You're stepping on my foot
Oops! I'm sorry. 哎哟! 对不起
I made a mistake. /My mistake
Oh, no! I missed the flight. 哦，不！
You did? 真的?
Ah, man! *man表示兴奋的和吃惊
Oh, my goodness! /Oh, my gosh!
Good heavens!
We have to decide what to do
That's the hard part. 这正是难点
That's the difficult part
I feel guilty. 我感到很内疚I was mean. 我太刻薄了，
Don't worry about it
It's all my fault
I feel bad about it
I feel horrible
I feel terrible
You look puzzled. 你看来很困惑
I can't understand this machine
You look confused
The idea haunts me. 那个念头总是萦绕着我
I can't get rid of the idea
I can't get it out of my mind